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Ionis Pharmaceuticals Study Results Of Olezarsen For Severe Hypertriglyceridemia Show Up To 72% Placebo-adjusted Mean Reduction In Fasting Triglyceride Levels At Six Months, With Reductions Sustained Through 12 Months

Author: Benzinga Newsdesk | November 08, 2025 10:13am

Groundbreaking pivotal study results of olezarsen for severe hypertriglyceridemia (sHTG) presented as a late breaker at AHA Scientific Sessions

– Up to 72% placebo-adjusted mean reduction in fasting triglyceride levels at six months, with reductions sustained through 12 months –

– 86% of olezarsen-treated patients achieved triglyceride levels less than 500 mg/dL, below the risk threshold for acute pancreatitis –

– First and only investigational treatment for sHTG to significantly reduce acute pancreatitis events –

– Data simultaneously published in The New England Journal of Medicine

Posted In: IONS

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