Bionano Genomics Highlighted Expanding Role Of Optical Genome Mapping In Genetic Disease Research At ASHG Conference

Author: Benzinga Newsdesk | October 23, 2025 08:07am

Bionano Genomics, Inc. (NASDAQ:BNGO) participated in The American Society of Human Genetics (ASHG) conference from October 14–18, 2025 in Boston. The event highlighted the potential for an expanding role of optical genome mapping (OGM) in genetic disease research. Multiple presentations and posters showcased its effectiveness in detecting structural variants (SVs) associated with a range of genetic conditions, including facioscapulohumeral muscular dystrophy (FSHD), prenatal, and postnatal disorders.

Key Highlights from ASHG 2025:

A total of nine studies, presented as either oral sessions or posters, demonstrated the effectiveness of OGM in detecting novel SVs that can be missed by traditional cytogenetic and sequencing techniques. These findings highlight the significant value OGM can have in addressing complex genetic conditions.

• Completely Resolved Structural Variants by OGM with adaptive sampling from CNV discovery. Li Fu, Yokohama City University Graduate School of Medicine, Japan
  
   
• Optical Genome Mapping and Other Techniques Resolve a Duchenne Muscular Dystrophy Sample. Ulrich Broeckel, Medical College of Wisconsin, USA
  
   
• Improved Algorithms for Optical Genome Mapping Workflows in Constitutional Disease and Oncology Applications. Andy Wing Chun Pang, Bionano, USA
  
   
• Project Baby Magnolia: Implementing OGM at the University of Mississippi Medical Center. Douglas McLaurin, University of Mississippi Medical Center, USA
  
   
• Comparison of Optical Genome Mapping, Chromosomal Microarray and Next-Generation Sequencing for Detection of Structural Variants in Rare Diseases. Kumiko Yanagi, National Center for Child Health and Development, Japan
  
   
• OGM Elucidates Complex Rearrangements Associated with Developmental Delay. Masanori Fujimoto, Nagoya City University Graduate School of Medical Sciences, Japan
  
   
• Leveraging Advanced Genomics in Rare Diseases: Outcomes from the University of Wisconsin Disease Program. Bryn Webb, University of Wisconsin School of Medicine and Public Health, USA
  
   
• Prospective Comparative Evaluation of Optical Genome Mapping, Mate-Pair Genome Sequencing, and Chromosomal Microarray Analysis in Prenatal Disorders. Matthew Hoi Kin Chau, The Chinese University of Hong, China
  
   
• Efficient Detection And Characterization of FSHD1 with Optical Genome Mapping. Trilochan Sahoo, Bionano Laboratories, USA
   

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