PacBio Announced Innovations To Its Revio And Vega Platforms To Lower Sequencing Costs, Add New Multiomic Capabilities, And Expand Support For Regulated Research Environments

Author: Benzinga Newsdesk | October 14, 2025 06:07am

• The advancements center on new SPRQ-Nx sequencing chemistry and consumables, which are designed to deliver PacBio's most affordable HiFi genome to date. Customers operating at scale could see as much as a 40% reduction from current costs, down to a price of less than $300 per genome. Additional improvements include 5hmC detection for epigenetic profiling and 21 CFR Part 11 compliance features for Vega. These updates reflect PacBio's continued investment in making its highly accurate long-read sequencing solutions accessible at scale for population genomics, clinical research, and production-scale environments.
• Beta testing of SPRQ-Nx chemistry on the higher throughput Revio is expected to begin in November 2025, with full commercial availability planned in 2026. Beta participants will be able to purchase 384 genomes of sequencing reagents for approximately $250 per genome. At launch, Revio systems running SPRQ-Nx will produce complete, multiomic native long-read genomes at the lowest cost in the market. PacBio intends to achieve these cost savings by enabling multiple runs per SMRT Cell while maintaining output per run, which will improve efficiency, reduce waste, and preserve PacBio's hallmark accuracy and data richness.
• Vega, PacBio's benchtop system, will integrate SPRQ-Nx chemistry and 5hmC detection capabilities in 2026. Vega will also add rapid two- and four-hour sequencing runs, designed for high-demand applications such as plasmid and targeted sequencing. These upgrades will include secure authentication and audit logging features to support 21 CFR Part 11 compliance for labs operating under regulated conditions.

Posted In: PACB