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IDEAYA Biosciences Reports Data From Phase 1/2 Combination Trial Of IDE397, And Trodelvy In MTAP-Deletion Urothelial Cancer

Author: Benzinga Newsdesk | September 08, 2025 08:07am

Overall response rate (ORR) of 57% (4/7; 3cPR+1uPR) in patients treated with a combination of 30 mg IDE397 plus 7.5mg/kg Trodelvy® (Dose level 2); ORR of 33% (3/9; 3cPR) at 15 mg IDE397 plus 10mg/kg Trodelvy® (Dose level 1)
Manageable safety profile at both expansion doses, consistent with known adverse events observed with each agent alone, with no treatment related serious adverse events observed at the IDE397 30mg and Trodelvy® 7.5 mg/kg expansion dose
Selection of recommended Phase 2 dose is targeted by end of 2025, with next update planned for a medical conference in H1 2026

Posted In: IDYA