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News

Palisade Bio Reports Phase 1 Results For PALI-2108, Showing Safety And Strong Colon Tissue Drug Levels As Company Prepares For Phase 2 Trial In 2026

Author: Benzinga Newsdesk | August 07, 2025 09:16am

PALI-2108 demonstrated to be safe and well tolerated with no serious adverse events (SAEs)

Extended half-life and local bioactivation support convenient once-daily dosing in ulcerative colitis (UC) and fibrostenotic Crohn's disease (FSCD)

Colon tissue drug levels exceeded target thresholds 36 hours post-dose in completed Phase 1a MAD cohort

Company advancing toward IND submission for Phase 2 study in H1 2026

Carlsbad, CA, Aug. 07, 2025 (GLOBE NEWSWIRE) -- Palisade Bio, Inc. (NASDAQ:PALI) ("Palisade", "Palisade Bio", or the "Company"), a clinical-stage biopharmaceutical company focused on developing and advancing novel therapeutics for patients living with autoimmune, inflammatory, and fibrotic diseases, today announced compelling new data from its ongoing clinical program evaluating PALI-2108, a first-in-class, ileocolonic-targeted PDE4 inhibitor, including positive topline results from its Phase 1b open-label cohort in patients with moderate-to-severe UC and colon tissue pharmacokinetic (PK) data from the Phase 1a multiple ascending dose (MAD) cohort.

Posted In: PALI

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