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Reported Saturday, Zentalis Presented Updated DENALI Part 1b Clinical Data Demonstrating 6.3-Month mDOR And ~35% ORR With Azenosertib Monotherapy In Cyclin E1+ Platinum-Resistant Ovarian Cancer

Author: Benzinga Newsdesk | March 17, 2025 03:17am
  • Azenosertib median duration of response (mDOR) updated to 6.3 months in the ongoing DENALI Part 1b clinical trial in patients with platinum-resistant ovarian cancer (PROC) and continues to demonstrate an objective response rate (ORR) of ~35% in response-evaluable patients
  • On track to initiate Part 2 of the ongoing DENALI clinical trial in 1H 2025, with registration-intent topline data anticipated by year end 2026
  • Company also presents preclinical combination data of azenosertib with microtubule inhibitor-based antibody-drug conjugates (ADCs), demonstrating synergistic antitumor effects

Posted In: ZNTL

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