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Reported Saturday, Sutro Highlights Late-Breaking Refrαme-O1 Data Demonstrating 32% ORR And 96% DCR With Optimized Luvelta Dosing In PROC Patients

Author: Benzinga Newsdesk | March 17, 2025 03:07am

Late-Breaking Oral Presentation Highlights:

At the selected optimized dose (5.2 mg/kg), luvelta achieved an ORR of 32%1 and a disease control rate (DCR) of 96% compared to an ORR of 13.8% and a DCR of 69% for the 4.3 mg/kg group.
The demonstrated clinical activity in the 5.2 mg/kg group was consistent in patients across all levels of FRα expression of 25% or greater, with an ORR of 30.8% and a DCR of 100% for positive staining (PS) 2+ ≥75% (eligible for approved FRα-targeting ADC) and an ORR of 33.3%1 and DCR of 91.7%1 for PS2+ < 75%.
Safety was consistent across dosing groups, with no new safety signals observed and neutropenia well-managed.
The majority of patients across both dose cohorts received prior bevacizumab.

Posted In: STRO