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NeuroBo Pharmaceuticals Inc (NASDAQ:NRBO) shares were down more than 6% at last check Wednesday.
The Boston-based company announced preclinical data for its novel “G-Protein-Coupled Receptor 119 (GPR119) agonist,” known as DA-1241.
The data from a study on mice suggests that DA-1241 — combined with Novo Nordisk A/S’s (NYSE:NVO) semaglutide (Wegovy) — improves liver fibrosis. It also demonstrates additive hepatoprotective effects compared to either treatment alone.
DA-1241 did not influence liver weight, the company said.
In contrast, semaglutide reduced body weight by approximately 25% and improved hepatomegaly in GAN DIO-MASH mice with or without combination treatment.
There was no additional weight loss in the combination group compared to semaglutide alone.
DA-1241 or semaglutide alone lowered collagen-positive area compared to the vehicle-treated group (17.8%, 17.1% vs. 25.8%, p < 0.05). Their combination therapy elicited a further reduction to 6.05% (p < 0.05) compared with each treatment alone.
Price Action: NRBO shares are down 6.11% at $4.30 at last check Wednesday.
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