GRAIL Presents New Data On Galleri And Its Methylation Platform At The Annual American Association For Cancer Research Meeting

Author: Benzinga Newsdesk | March 27, 2024 09:03am

New Data Will Highlight Use of GRAIL's Targeted Methylation Platform Across Early Cancer Detection and Precision Oncology

Longer-term Data Underscore the Potential Value of GRAIL's Galleri® for Repeat Screening for Clinically Significant Cancers

GRAIL, LLC, a healthcare company whose mission is to detect cancer early when it can be cured, will present new data on the clinical utility of its Methylation Platform across the cancer continuum, and the impact of multi-cancer early detection (MCED) testing in guiding diagnostic evaluation at the American Association for Cancer Research (AACR) Annual Meeting in San Diego, Calif., April 5-10, 2024.

"The data we are presenting at AACR continue to support the potential of GRAIL's Methylation Platform to transform cancer care and the potential benefits of population-scale asymptomatic (or early) cancer detection," said Jeffrey Venstrom, MD, Chief Medical Officer at GRAIL. "Our longer-term research demonstrates that adding MCED tests like Galleri to guideline-recommended screenings can help direct diagnostic evaluation and underscores the potential value of repeat MCED screening. Additionally, new data from our Methylation Platform suggests the ability to identify relevant cancer subtypes using a single blood test, helping to enable precision medicine and biomarker discovery."

In the MCED setting, GRAIL is honored to present 3 oral presentations at AACR:

• Demonstrating the first real-world evaluation of repeat MCED / Galleri testing showing the potential value of adding repeat MCED screening. The timeframe for repeat testing occurred 10-18 months from initial MCED testing.
• Exhibiting 4-year overall survival follow-up demonstrating the prognostic significance of detecting cancer with a methylation-based cfDNA platform like Galleri.
• Illustrating data demonstrating the power of Galleri to preferentially detect high grade, clinically significant prostate cancer over indolent cases.

In the precision oncology setting, GRAIL will discuss the adaptability of its Methylation Platform in identifying cancer histological and molecular subtypes through blood samples.

Oral Presentations

Title: Early Real-World Experience with Repeat Multi-Cancer Early Detection (MCED) Testing

Abstract Number: #3891

Session Category: Clinical Research

Session Title: Application of Real-World Evidence to Cancer Care

Date/Time: Monday, Apr. 8, 2024 from 2:30 PM - 4:30 PM

Location: Room 6 CF - Upper Level - Convention Center

Title: A Targeted Methylation-Based Multi-Cancer Early Detection Blood Test Preferentially Detects High-Grade Prostate Cancer and Minimizes Overdiagnosis

Abstract Number: #1264

Session Category: Prevention / Early Detection / Interception

Session Title: Multi-Cancer Early Detection Testing: Where Are We?

Date/Time: Sunday, Apr. 7, 2024 from 3:00 PM - 5:00 PM

Location: Room 28 - Upper Level - Convention Center

Title: Prognostic Significance of Blood-Based Multi-Cancer Detection in Cell-Free DNA: 4-Year Outcomes Analysis

Abstract Number: #3895

Session Category: Clinical Research

Session Title: Early Detection and Progression Biomarkers

Date/Time: Monday, Apr. 8, 2024 from 2:30 PM - 4:30 PM

Location: Ballroom 6 B - Upper Level - Convention Center

Poster Sessions

Title: PATHFINDER 2: A Prospective Study to Evaluate Safety and Performance of a Multi-Cancer Early Detection Test in a Population Setting

Abstract Number: #4784

Session Category: Prevention / Early Detection / Interception

Session Title: Population-Based Screening

Date/Time: Tuesday, Apr. 9, 2024 from 9:00 AM - 12:30 PM

Location: Poster Section 32

Title: Identification of Cancer Subtypes with a ctDNA-based Targeted Methylation Assay

Abstract Number: #7566

Session Category: Clinical Research

Session Title: Molecular Biology in Clinical Oncology: Characterizing and Modulating Epigenetics and Gene Expression

Date/Time: Wednesday, Apr. 10, 2024 from 9:00 AM - 12:30 PM

Location: Poster Section 43

Title: Most Cancer Deaths are Unaddressed by Current Screening Paradigms

Abstract Number: #6075

Session Category: Prevention / Early Detection / Interception

Session Title: Biomarker-Based Screening

Date/Time: Tuesday, Apr. 9, 2024 from 1:30 PM - 5:00 PM

Location: Poster Section 31

Title: Association of Circulating Free DNA (cfDNA) Maximum Variant Allele Frequency (mVAF) Levels with Clinical Outcomes in Patients (pts) with Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) Treated with Pembrolizumab (pembro) + Chemotherapy (chemo) in the Phase 2 KEYNOTE-782 Trial

Abstract Number: #LB107

Session Category: Clinical Research

Session Title: Late-Breaking Research: Clinical Research 1

Date/Time: Monday, Apr. 8, 2024 from 9:00 AM - 12:30 PM

Location: Poster Section 51

Posted In: ILMN