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Poster presentation of FHD-909, a first-in-class oral BRM selective inhibitor, highlighting preclinical efficacy and safety in multiple mouse models of NSCLC; IND filing planned in Q2 2024
Oral presentation demonstrating preclinical efficacy and tolerability data for Selective CBP and Selective EP300 degraders; Significant anti-tumor activity observed, with no thrombocytopenia as historically observed with dual CBP/EP300 inhibitors
Additional poster presentation demonstrating long-acting degrader capabilities confirming up to once-a-month dosing for protein degrader programs
CAMBRIDGE, Mass., March 05, 2024 (GLOBE NEWSWIRE) -- Foghorn® Therapeutics Inc. (NASDAQ:FHTX), a clinical-stage biotechnology company pioneering a new class of medicines that treat serious diseases by correcting abnormal gene expression, today announced that preclinical data for its pipeline programs, including the first presentation of preclinical data for FHD-909, a potential first-in-class BRM (SMARCA2) selective inhibitor will be presented at the 2024 American Association for Cancer Research (AACR) Annual Meeting being held April 5-10, 2024 in San Diego, California. In addition to the FHD-909 poster, the Company will have a symposium presentation, a town hall talk, and poster presentations on its selective CBP degrader and selective EP300 degrader programs.
"Our 2024 AACR presentations showcase the significant progress that Foghorn has made advancing multiple potential first-in-class medicines, based on our unique capabilities targeting the chromatin regulatory system" said Adrian Gottschalk, President and Chief Executive Officer of Foghorn. "We are excited to present new preclinical data supporting the potent activity of FHD-909, a potentially first-in-class oral BRM selective inhibitor with robust anti-tumor activity, and we look forward to continued progress with Lilly to advance it to the clinic with an IND planned in Q2 2024."
Mr. Gottschalk added, "We will also have presentations and posters highlighting the differentiated profile of our Selective CBP and Selective EP300 degrader programs, demonstrating selective degradation resulting in significant anti-tumor activity but without the thrombocytopenia that has often been observed for dual CBP/EP300 inhibitors. In addition, we will present data highlighting our long-acting formulation capabilities that enable up to once-a-month dosing for protein degraders, which we believe meaningfully differentiate our programs and platform."
Presentation Details
FHD-909
Poster Title: Discovery of selective BRM (SMARCA2) ATPase inhibitors for the treatment of BRG1 (SMARCA4) mutant cancers
Session: Experimental & Molecular Therapeutics
Poster Number: 3230 / 14
Session Date/Time: Monday, April 8, 1:30 p.m. – 5 p.m.
Presenter: Janice Lee, Director, Biology, Foghorn Therapeutics
CBP and EP300 Programs
Oral Presentation Title: Targeting Chromatin Regulatory Cancer Drivers with Degraders
Symposium Session: SY12 - Molecular Glues, PROTACs, and Next-Gen Degraders: Discovery and Early Preclinical Advances
Session Date/Time: Tuesday, April 9, 10:15 a.m. – 11:45 a.m.
Presenter: Steve Bellon, Chief Scientific Officer, Foghorn Therapeutics
Town Hall Title: Inhibit or Degrade?
Symposium Session: TM04 – Losing our inhibitions – is (protein) degradation preferred?: A chemistry in Cancer Research Working Group Town Hall Meeting
Session Date/Time: Monday, April 8, 6:00 p.m. – 8 p.m. Presenter: Laura La Bonte, Senior Director, Biology, Foghorn Therapeutics
Poster Title: Identification of selective CBP degraders with robust preclinical PK, PD, efficacy and safety across solid tumor indications
Session: Experimental & Molecular Therapeutics
Poster Number: 6067 / 26
Session Date/Time: Tuesday, April 9, 1:30 p.m. – 5 p.m.
Presenter: Darshan Sappal, Director, Biology, Foghorn Therapeutics
Poster Title: Discovery of potent and selective EP300 degraders with anti-cancer activity
Session: Experimental & Molecular Therapeutics
Poster Number: 6064 / 23
Session Date/Time: Tuesday, April 9, 1:30 p.m. – 5 p.m.
Presenter: Mark Zimmerman, Principal Scientist, Biology, Foghorn Therapeutics
FHD-609
Poster Title: Long acting injectable FHD-609 micro-suspension: A potent BRD9 degrader with comparable efficacy, reduced frequency of dosing in preclinical models
Session: Experimental & Molecular Therapeutics
Poster Number: 7185 / 26
Session Date/Time: Wednesday, April 10, 9 a.m. – 12:30 p.m.
Presenter: Mei Yun Lin, Senior Scientist, Pharmacology, Foghorn Therapeutics
The presentation and the posters will be accessible under the Science section of the Company's website after the conference.
About FHD-909
FHD-909 (a.k.a. LY4050784) is a highly potent, allosteric and orally available small molecule that selectively inhibits the ATPase activity of BRM (SMARCA2) over its closely related paralog BRG1 (SMARCA4), two proteins that are the catalytic engines across all forms of the BAF complex, one of the key regulators of the chromatin regulatory system. In preclinical studies, tumors with mutations in BRG1 rely on BRM for BAF function. FHD-909 has shown significant anti-tumor activity across multiple BRG1-mutant lung tumors.
Posted In: FHTX
