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Shattuck Labs Inc (NASDAQ:STTK) announced initial topline dose-expansion data from its ongoing Phase 1A/B trial of SL-172154 in combination with Azacitidine (AZA) in frontline high-risk myelodysplastic syndromes (HR-MDS) and TP53 mutant (TP53m) acute myeloid leukemia (AML) patients.
The study observed an Objective Response Rate (ORR) of 79% in frontline HR-MDS patients, primarily with TP53 mutations, with an initial complete response (CR)/marrow complete response (mCR) rate of 64%.
Observed 27% initial CR/complete response with incomplete hematologic recovery (CRi) in frontline TP53m AML patients, and 5/11 evaluable patients achieved stable disease with decreasing blast counts and peripheral blood count improvement.
Safety: Preliminary data suggest that SL-172154 has an acceptable safety and tolerability profile in combination with azacitidine.
Price Action: STTK shares are up 91.3% at $4.03 on the last check Wednesday.
Posted In: STTK