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Poseida Therapeutics Presented Early Results From Its Phase 1 Trial Of Allogeneic CAR-T P-BCMA-ALLO1 In Relapsed-Refractory Multiple Myeloma At The 65th ASH Annual Meeting

Author: Benzinga Newsdesk | December 11, 2023 03:46am

82% ORR and deep clinical responses from off-the-shelf, allogeneic BCMA-targeted CAR-T in heavily pretreated patients receiving adequate lymphodepletion
100% ORR in these patients who were not previously treated with a BCMA-targeted bispecific T cell-engaging antibody
Favorable emerging safety and reliability profile, with all (100%) intent-to-treat (ITT) patients receiving therapy, no GvHD or dose-limiting toxicities and low incidences of CRS and neurotoxicity observed (all ≤ Grade 2)
Preliminary data show allogeneic TSCM-rich CAR-T cells trafficking to bone marrow, differentiating to cell-killing effector T cells and persisting at least 6 weeks
Two additional poster presentations highlight advancements across the Company's cell and gene therapy programs and platforms

Posted In: PSTX