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Two oral presentations and three poster presentations elucidate new data relevant to rusfertide, a hepcidin mimetic with potential therapeutic value in the treatment of Polycythemia Vera and other disease indications
NEWARK, CA / ACCESSWIRE / November 2, 2023 / Protagonist Therapeutics, Inc. (NASDAQ:PTGX) ("Protagonist" or "the Company") announced today that five abstracts relevant to the Company's rusfertide program have been accepted for presentation at the 65th American Society of Hematology Annual Meeting and Exposition (ASH), taking place December 9-12, 2023 in San Diego, California.
"We are extremely pleased to present a broad cross-section of new data at ASH this year," said Dinesh V. Patel, Ph.D., President and Chief Executive Officer of Protagonist. "Among these presentations are data which underscore the potential for rusfertide to improve markers of iron deficiency in polycythemia vera, and to sustain improved outcomes such as hematocrit control in PV patients over a two-year time horizon.
Additionally, we look forward to sharing data that elucidate important epidemiological aspects of PV, drawing upon an extensive analysis of claims data and other resources. Finally, we look forward to presenting new preclinical data demonstrating improved disease parameters with a hepcidin mimetic treatment in a mouse model for sickle cell disease."
Dr. Patel continued: "Congratulations to our internal team and external partners for the dedication and rigor they have applied to these important areas of scientific research. Taken together, these presentations constitute major contributions to the field of hematology."
Oral presentation details are as follows:
Title: Real-World Analysis of Thromboembolic Event Rates in Patients in the United States with Polycythemia Vera
Presenting author: Andrew T. Kuykendall, MD (Moffitt Cancer Center, Tampa, FL)
Session Name: 904. Outcomes Research - Non-Malignant Conditions: Across the Age Spectrum: Thromboembolism Outcomes in Adult and Pediatric Patients
Session Date: Saturday, December 9, 2023
Session Time: 9:30-11:00 AM PST
Presentation Time: 10:30 AM PST
Room: Marriott Marquis San Diego Marina, Pacific Ballroom Salons 18-19
Publication Number: 137
Submission ID: 180309
Title: Durability of Hematocrit Control in Polycythemia Vera with the First-in-Class Hepcidin Mimetic Rusfertide: Two-Year Follow up Results from the Revive Study
Presenting author: Ellen K. Ritchie, MD (Weill Cornell Medical College New York Presbyterian, NY)
Session Name: 634. Myeloproliferative Syndromes: Clinical and Epidemiological: Treatment and Outcomes in MPNs
Session Date: Monday, December 11, 2023
Session Time: 10:30 AM - 12:00 PM PST
Presentation Time: 10:30 AM PST
Room: San Diego Convention Center, Ballroom 20CD
Publication Number: 745
Submission ID: 178253
Poster presentation details are as follows:
Title: Iron Restricted Erythropoiesis Under Hepcidin Mimetic Treatment (PN23114) Improved Disease Parameters in a Mouse Model for Sickle Cell Disease
Presenting author: Roopa Taranath, PhD (Protagonist Therapeutics, Inc., Newark, CA)
Session Name: 113. Sickle Cell Disease, Sickle Cell Trait and Other Hemoglobinopathies, Excluding Thalassemias: Basic and Translational: Poster I
Session Date: Saturday, December 9, 2023
Presentation Time: 5:30-7:30 PM PST
Location: San Diego Convention Center, Halls G-H
Publication Number: 1117
Submission ID: 182472
Title: Rusfertide Improves Markers of Iron Deficiency in Patients with Polycythemia Vera
Presenting author: Yelena Ginzburg, MD (Mount Sinai, New York, NY)
Session Name: 634. Myeloproliferative Syndromes: Clinical and Epidemiological: Poster II
Session Date: Sunday, December 10, 2023
Presentation Time: 6:00-8:00 PM PST
Location: San Diego Convention Center, Halls G-H
Publication Number: 3208
Submission ID: 178334
Title: Prevalence of Second Cancers in Patients with Polycythemia Vera (PV): A Retrospective Analysis of US Real-World Claims Data
Presenting author: Naveen Pemmaraju, MD (MD Anderson Cancer Center, Houston, TX)
Session Name: 634. Myeloproliferative Syndromes: Clinical and Epidemiological: Poster II
Session Date: Sunday, December 10, 2023
Presentation Time: 6:00-8:00 PM PST
Location: San Diego Convention Center, Halls G-H
Publication Number: 3190
Submission ID: 180045
Posted In: PTGX
